Alcohols and polyols

Organic compounds containing one or more hydroxyl functional groups bonded to a carbon atom; hydroxyls consist of an oxygen atom bonded to a hydrogen atom. Alcohols exist in chain, or as closed rings. Polyols contain two or more hydroxyl groups.

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4,606 – 4,620 of 5,341 results

4,606

Medchemexpress LLC AMXI-5001 hydrochloride | 00-00-0 | 98.1% | C25H21ClFN5O3 | 10MG

AMXI-5001 hydrochloride is a research-grade small molecule described as a dual inhibitor of PARP1/2 and microtubule polymerization. It shows potent cellular activity against PARP and tubulin targets, with reported favorable metabolic stability and oral bioavailability, and is intended for preclinical anticancer research.

Dual mechanism: inhibits PARP1/2 and tubulin polymerization.
Potent PARP inhibition with low nanomolar IC50s and tubulin inhibition in the micromolar range.
Orally bioavailable with favorable pharmacokinetic properties.
Suitable for in vitro and in vivo anticancer studies.
High purity for research applications.

Pricing & Availability

4,607

Medchemexpress LLC Pociredir hydrochloride | 2490676-19-0 | 99.9% | 439.87 | 10 MM/1 ML

Pociredir hydrochloride, also known as FTX-6058, is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). It is utilized in research for select hemoglobinopathies like sickle cell disease and β-thalassemia by inducing HbF protein expression in cell and murine models.

Potent and orally active inhibitor of EED
Induces HbF protein expression in cell and murine models
Used in research for select hemoglobinopathies, including sickle cell disease and β-thalassemia
Inhibits PRC2 via binding to EED

Pricing & Availability

4,608

Medchemexpress LLC PF-562271 (hydrochloride) | 939791-41-0 | 98.10% | 543.95 | 5 MG

PF-562271 hydrochloride is a potent, ATP-competitive, and reversible inhibitor targeting FAK (Focal Adhesion Kinase) and Pyk2 (Proline-rich tyrosine kinase 2) kinases, with IC50 values of 1.5 nM and 13 nM, respectively.

Potent, ATP-competitive, and reversible kinase inhibitor.
Selectively targets FAK and Pyk2 kinases.
Exhibits IC50s of 1.5 nM for FAK and 13 nM for Pyk2.
Also inhibits CDK2/E, CDK5/p35, CDK1/B, and CDK3/E.
Impairs cell viability in various cell lines, including Ewing sarcoma.
Inhibits FAK phosphorylation in vivo in a dose-dependent manner.
Demonstrates positive effects on bone tumors, including decreased tumor growth and deposition of new bone.

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4,609

Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 500 MG

SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. This compound can be used for type 2 diabetes research.

Inhibits human TXNIP promoter activity and reduces TXNIP mRNA and protein levels in INS-1 cells.
Lowers glucagon secretion in TC1-6 cells and decreases glucagon secretion and action in vivo.
Reduces glucagon-induced glucose output from primary hepatocytes and blocks hepatic glucose output in vivo.
Reverses obesity- and Streptozotocin (STZ)-induced diabetes and hepatic steatosis in mice.
Orally bioavailable.
Well-tolerated in male C57BL/6J mice.

Pricing & Availability

4,610

Medchemexpress LLC Clorgyline hydrochloride | 17780-75-5 | 99.9% | C13H16Cl3NO | 50 MG

Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) used in scientific research. It has minimal effect on conjugated dopamine (DA) amounts in superfusates of rat striatum slices. This compound contains an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Irreversible and selective inhibitor of monoamine oxidase A (MAO-A)
Structurally related to Pargyline
Contains an Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide groups
Increases nicotine infusions and motivation to obtain nicotine in rats at 2 mg/kg daily for 28 days
Pretreatment with 1 mg/kg intravenously for 1 hour has little effect on the efflux of conjugated dopamine (DA) and p-tyramine-evoked release of conjugated DA from slices of rat striatum

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4,611

Medchemexpress LLC Fadrozole hydrochloride | 102676-31-3 | 99.9% | C14H14ClN3 | 100 MG

Fadrozole hydrochloride (CGS 16949A) is a potent, selective, and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. Intended for research use only, this compound effectively inhibits estrogen and progesterone production. It has demonstrated efficacy in preventing the development of various spontaneous neoplasms and reducing parasite burden in animal models.

Potent, selective, and nonsteroidal aromatase inhibitor
Inhibits estrogen production in hamster ovarian slices
Inhibits progesterone production
Prevents development of benign and malignant spontaneous mammary neoplasms
Reduces incidence of spontaneous hepatocellular tumors
Reduces parasite burden in male and female mice

Pricing & Availability

4,612

Medchemexpress LLC Sri-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 250 MG

Inhibits activity of human TXNIP promoter in INS-1 cells.
Inhibits mRNA and protein levels of TXNIP.
Inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter.
Lowers glucagon secretion in TC1-6 cells.
Inhibits glucagon-induced glucose output from primary hepatocytes.
Decreases glucagon secretion and blocks hepatic glucose output in mice.
Reverses obesity- and STZ-induced diabetes and hepatic steatosis in mice.

Pricing & Availability

4,613

Medchemexpress LLC BMY-25368 hydrochloride | 86134-36-3 | ≥97.0% | 379.88 | C19H26ClN3O3 | 10 MG

BMY-25368 hydrochloride is a research reagent used as a histamine H2 receptor antagonist and gastric acid secretion inhibitor. Supplied as a hydrochloride salt with documented molecular and purity data, it is intended for preclinical in vitro and in vivo studies where receptor antagonism or gastric secretion modulation is required.

Histamine H2 receptor antagonist for gastric acid secretion studies.
Hydrochloride salt form for improved solubility and stability.
High purity (≥97.0% by NMR) suitable for research use.
Verified molecular weight (379.88) and formula for accurate dosing.
Available in small-scale quantities for preclinical experiments.

Pricing & Availability

4,614

Medchemexpress LLC Nimustine hydrochloride | 55661-38-6 | MFCD01676942 | 98.2% | C9H14Cl2N6O2 | 10MG

Nimustine hydrochloride is the hydrochloride salt of nimustine, an alkylating antitumor agent used in research to induce DNA damage and study DNA-damage response pathways. It produces DNA double-strand breaks and inter-strand crosslinks and activates signaling cascades involved in the DNA damage response.

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4,615

Medchemexpress LLC Ly 303511 hydrochloride | 2070014-90-1 | 98.9% | 342.82 g·mol⁻¹ | C19H19ClN2O2 | 10 MG

LY 303511 hydrochloride is a research-grade small molecule (CAS 2070014-90-1) that acts as a structural analogue of LY294002; it enhances TRAIL sensitivity in SHEP-1 neuroblastoma cells and reversibly blocks potassium currents in MIN6 insulinoma cells. Supplied as a 10 mg solid with high purity for in vitro studies. Store sealed and protected from moisture.

High purity (98.9%) suitable for screening and biochemical assays.
Compact 10 mg pack for dose-response and early-stage experiments.
Solid form stable under recommended storage temperatures when sealed.
Documented activity on TRAIL sensitivity and potassium current modulation.
CAS number provided for precise chemical identification.

Pricing & Availability

4,616

Medchemexpress LLC Clemizole hydrochloride | 1163-36-6 | 99.99% | 362.30 | 100 MG

Clemizole hydrochloride is an H1 histamine receptor antagonist that substantially inhibits HCV replication and is an inhibitor of the TRPC5 channel. It has an IC50 of 24 nM for RNA binding by NS4B and an EC50 of 8 μM for viral replication. For research use only.

H1 histamine receptor antagonist.
Substantially inhibits HCV replication.
Inhibitor of TRPC5 channel.
EC50 of 8 μM for viral replication.
IC50 of 24 nM for RNA binding by NS4B.
Inhibits HCV RNA replication in cell culture mediated by suppression of NS4B's RNA binding with little toxicity for the host cell.
Efficiently blocks TRPC5 currents and Ca2+ entry in the low micromolar range (IC50=1.0-1.3 μM).
Exhibits six-fold selectivity for TRPC5 over TRPC4β (IC50=6.4 μM) and almost 10-fold selectivity over TRPC3 (IC50=9.1 μM) and TRPC6 (IC50=11.3 μM).

Pricing & Availability

4,617

Medchemexpress LLC VU0453379 hydrochloride | 99.0% | 471.03 | 1 ML

VU0453379 hydrochloride is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R). It exhibits an EC50 of 1.3 μM.

Highly selective positive allosteric modulator.
Central nervous system (CNS) penetrant.
Modulates glucagon-like peptide-1R (GLP-1R).
Demonstrates an EC50 of 1.3 μM.

Pricing & Availability

4,618

Medchemexpress LLC (S,S,S)-AHPC hydrochloride | 2115897-23-7 | 99.2% | 467.02 | C22H31ClN4O3S | 5MG

(S,S,S)-AHPC hydrochloride is the hydrochloride salt of an AHPC-derived VHL ligand used as a building block and negative control in E3 ligase recruitment and PROTAC research. It facilitates the study of VHL-mediated ubiquitination and proteasomal degradation, and is supplied for synthetic and assay applications in small research quantities.

High purity 99.2%
Molecular weight 467.02
Chemical formula C22H31ClN4O3S
Solid white to yellow appearance
Suitable as a negative control and VHL ligand building block for PROTAC design
Available in small milligram pack sizes for research use

Pricing & Availability

4,619

Medchemexpress LLC Gyki 53655 (hydrochloride) | 143692-48-2 | MFCD01941362 | 98.4% | 388.85 g·mol⁻¹ | C19H21ClN4O3 | 1 ML

GYKI 53655 hydrochloride is a selective, non-competitive antagonist of AMPA receptors used in electrophysiology and receptor pharmacology research. The hydrochloride salt is available as a high-purity solid or as a ready-to-use 10 mM solution in DMSO.

Selective non-competitive AMPA and kainate receptor antagonist.
Available as 10 mM solution in DMSO (1 mL) or as solid doses.
High purity (~98.4%) suitable for in vitro studies.
Molecular weight 388.85 g·mol⁻¹ and formula C19H21ClN4O3.
Recommended storage: solid at 4°C; solution at -80°C for long-term storage.

Pricing & Availability

4,620

Medchemexpress LLC Acotiamide hydrochloride | 185104-11-4 | 99.6% | 25 MG

Acotiamide hydrochloride is the hydrochloride salt of acotiamide, provided as a research-grade solid reagent used to study gastric motility, delayed gastric emptying, and related gastrointestinal disorders. It is supplied in small pack sizes with high reported purity suitable for analytical and in vitro research.

Orally active, reversible acetylcholinesterase inhibitor (reported IC50 ~1.79 μM).
Hydrochloride salt for improved stability and solubility.
High reported purity for research applications (reported ~99.6%).
Molecular formula C21H31ClN4O5S; molecular weight 487.01.
Available in small research pack sizes such as 25 mg.

Pricing & Availability

Alcohols and polyols

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Medchemexpress LLC AMXI-5001 hydrochloride | 00-00-0 | 98.1% | C25H21ClFN5O3 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Pociredir hydrochloride | 2490676-19-0 | 99.9% | 439.87 | 10 MM/1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PF-562271 (hydrochloride) | 939791-41-0 | 98.10% | 543.95 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Clorgyline hydrochloride | 17780-75-5 | 99.9% | C13H16Cl3NO | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Fadrozole hydrochloride | 102676-31-3 | 99.9% | C14H14ClN3 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Sri-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BMY-25368 hydrochloride | 86134-36-3 | ≥97.0% | 379.88 | C19H26ClN3O3 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Nimustine hydrochloride | 55661-38-6 | MFCD01676942 | 98.2% | C9H14Cl2N6O2 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ly 303511 hydrochloride | 2070014-90-1 | 98.9% | 342.82 g·mol⁻¹ | C19H19ClN2O2 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Clemizole hydrochloride | 1163-36-6 | 99.99% | 362.30 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC VU0453379 hydrochloride | 99.0% | 471.03 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S,S,S)-AHPC hydrochloride | 2115897-23-7 | 99.2% | 467.02 | C22H31ClN4O3S | 5MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Gyki 53655 (hydrochloride) | 143692-48-2 | MFCD01941362 | 98.4% | 388.85 g·mol⁻¹ | C19H21ClN4O3 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Acotiamide hydrochloride | 185104-11-4 | 99.6% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More